IMPACT
What Are We Trying to Learn?
The purpose of this study is to understand how our brains change with age and which changes affect walking, thinking, and memory as we get older. Using a variety of tests, we collect data on brain structure, brain blood vessels, inherited traits, walking, thinking, and memory. Our goal is to identify ways to prevent walking, thinking, and memory problems as we get older and what changes in brain structure and function lead to walking, thinking, and memory problems in old age.
Despite having brain structural changes as they age, there are individuals who continue to have normal walking, thinking, and memory across their lives. Understanding the differences between these individuals and those who develop walking, thinking, and memory problems will help us identify ways to prevent thinking and memory problems in our aging population.
What Does Participation in the Study Involve?
There are five types of tests in the study. We can split these tests across two days. You will have one appointment lasting an hour and a half, and a second appointment lasting two and a half hours. Some people prefer to do all tests in one day. In that case, you will have an appointment lasting five hours.
We will do all tests once this year as a baseline measurement, then again at one follow-up in two years to see how things have changed.
Here is a brief overview of what the five types of tests – including timing – involve.
1. Thinking and Memory
These are memory games. These memory games are done using pen and paper or using an iPad.
Total time: 40-50 minutes.
2. Walking
These tests involve walking back and forth on a mat that records your footsteps.
Total time: 10 minutes.
3. Ultrasound
We put a small headset on your head to measure the blood flow in your brain. Then you do a few more memory games so we can see how your blood flow changes when you are being challenged. This is a completely non-invasive procedure.
About one in four people do not have the correct anatomy for the ultrasound tests. We do not know this until we put the helmet on you. We may skip the ultrasound tests depending on the structure of your skull.
Total time: 30-60 minutes.
4. MRI Scan
We will use an MRI machine to scan your brain. The MRI machine uses magnets to take a picture of your brain structure. The MRI machine does not use radiation.
Total time: 60 minutes.5. Blood Draw
We will draw about three tablespoons of blood to look for proteins and genes that may be important in brain function and aging.
What Do I Receive for My Participation?
If you complete all five tests this year, we will compensate you with $300. If you complete all five tests at the follow-up in two years, we will compensate you with another $350.
After each appointment, we will provide you with free copies of your MRI scans, your other test results, and more information on how to keep your brain healthy.
Where Does the Study Take Place?
We complete all testing at the Northwestern Medicine campus in downtown Chicago.
Still have questions? Contact us here!